Material Information
- Title:
- GENETIC DETERMINANTS FOR THE EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES IN LUNG CANCER
- Physical Description:
- Book
- Language:
- English
- Creator:
- Pope, Phillip Edward
- Publisher:
- New College of Florida
- Place of Publication:
- Sarasota, Fla.
- Publication Date:
- 2014
Thesis/Dissertation Information
- Degree:
- Bachelor's ( B.A.)
- Degree Grantor:
- New College of Florida
- Degree Divisions:
- Natural Sciences
- Area of Concentration:
- Applied Mathematics, Physics
Subjects
- Genre:
- Electronic Thesis or Dissertation
bibliography ( marcgt ) theses ( marcgt )
Notes
- Abstract:
- In this thesis we investigate the role of genetic variants in epigenetic phenomena. Specifically, we
study the correlation between single nucleotide polymorphisms (SNPs), a type of genetic variant, and
the epigenetic event DNA methylation. This work is in the context of lung cancer: the genes selected
are tumor suppressors related to lung carcinogenesis. In general, disruption of DNA methylation
patterns is associated with cancer, and genetic variants are associated with epigenomic variation.
Beta regression was used to model the proportion of DNA methylation explained by categorical
SNP variables. We provide evidence for SNPs as in-cis genetic determinants for the epigenetic
silencing of tumor suppressor genes in lung carcinogenesis. Several findings maintain significance
after multiple testing correction. These findings support the hypothesis that genetic variants can
influence phenotype through the epigenome.
- Thesis:
- Thesis (B.A.) -- New College of Florida, 2014
- General Note:
- RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
- Bibliography:
- Includes bibliographical references.
- General Note:
- This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
- General Note:
- Faculty Sponsor: McDonald, Patrick
- Statement of Responsibility:
- by Phillip Edward Pope
Record Information
- Source Institution:
- New College of Florida
- Holding Location:
- New College of Florida
- Rights Management:
- Applicable rights reserved.
- Classification:
- S.T. 2014 P6
- System ID:
- AA00024792:00001
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