GENETIC DETERMINANTS FOR THE EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES IN LUNG CANCER

Permanent Link:

http://ncf.sobek.ufl.edu/AA00024792/00001

Material Information

Title:

GENETIC DETERMINANTS FOR THE EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES IN LUNG CANCER

Physical Description:

Book

Language:

English

Creator:

Pope, Phillip Edward

Publisher:

New College of Florida

Place of Publication:

Sarasota, Fla.

Publication Date:

2014

Thesis/Dissertation Information

Degree:

Bachelor's ( B.A.)

Degree Grantor:

New College of Florida

Degree Divisions:

Natural Sciences

Area of Concentration:

Applied Mathematics, Physics

Faculty Sponsor:

McDonald, Patrick

Subjects

Genre:

Electronic Thesis or Dissertation
bibliography   ( marcgt )
theses   ( marcgt )

Notes

Abstract:

In this thesis we investigate the role of genetic variants in epigenetic phenomena. Specifically, we study the correlation between single nucleotide polymorphisms (SNPs), a type of genetic variant, and the epigenetic event DNA methylation. This work is in the context of lung cancer: the genes selected are tumor suppressors related to lung carcinogenesis. In general, disruption of DNA methylation patterns is associated with cancer, and genetic variants are associated with epigenomic variation. Beta regression was used to model the proportion of DNA methylation explained by categorical SNP variables. We provide evidence for SNPs as in-cis genetic determinants for the epigenetic silencing of tumor suppressor genes in lung carcinogenesis. Several findings maintain significance after multiple testing correction. These findings support the hypothesis that genetic variants can influence phenotype through the epigenome.

Thesis:

Thesis (B.A.) -- New College of Florida, 2014

General Note:

RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE

Bibliography:

Includes bibliographical references.

General Note:

This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.

General Note:

Faculty Sponsor: McDonald, Patrick

Statement of Responsibility:

by Phillip Edward Pope

Record Information

Source Institution:

New College of Florida

Holding Location:

New College of Florida

Rights Management:

Applicable rights reserved.

Classification:

S.T. 2014 P6

System ID:

AA00024792:00001