Material Information
- Title:
- Analysis of Copy Number Variation Association with GWAS Methylation Data
- Physical Description:
- Book
- Language:
- English
- Creator:
- Machusko, Jr., Steven Joseph
- Publisher:
- New College of Florida
- Place of Publication:
- Sarasota, Fla.
- Publication Date:
- 2014
Thesis/Dissertation Information
- Degree:
- Bachelor's ( B.A.)
- Degree Grantor:
- New College of Florida
- Degree Divisions:
- Natural Sciences
- Area of Concentration:
- Biochemistry
Subjects
- Genre:
- bibliography ( marcgt )
theses ( marcgt )
government publication (state, provincial, territorial, dependent) ( marcgt )
born-digital ( sobekcm )
Electronic Thesis or Dissertation
Notes
- Abstract:
- This thesis examined whether CNVs have a statistically significant effect on the
methylation status of a select group of genes previously found to have an association with
lung cancer. Data from 1200 genotyped sputum samples from 1200 individuals of the
Lovelace Smokers Cohort was analyzed to find the copy number variant composition of
each sample. An association analysis between the found CNVs and data on each sample
from a 12-gene methylation panel was then performed to determine any statistical
significance between CNVs and the methylation phenotype. An ontology association
analysis using the GREAT gene ontology tool was then performed on any SNP found to
be significant in order find the genomic location of that SNP and assess any association it
may have with any genes or gene regulatory regions. Even though the results of the
CNV-methylation analysis lack statistical significance after Bonferroni adjustment, there
is still valuable information in the ranking of association in the GREAT results. Many of
the significantly enriched annotations were highly significant after GREAT multiple
testing correction. While this study was unable to significantly reject the null hypothesis
of no association between CNVs and methylation of the 12-gene panel, the results of the
GREAT analysis warrant further work on this type of analysis.
- Statement of Responsibility:
- by Steven Joseph Machusko, Jr.
- Thesis:
- Thesis (B.A.) -- New College of Florida, 2014
- General Note:
- RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
- Bibliography:
- Includes bibliographical references.
- General Note:
- This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
- General Note:
- Faculty Sponsor: McDonald, Patrick; Ryba, Tyrone
Record Information
- Source Institution:
- New College of Florida
- Holding Location:
- New College of Florida
- Rights Management:
- Applicable rights reserved.
- Resource Identifier:
- Classification:
- S.T. 2014 M33
- System ID:
- AA00024768:00001
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