Material Information
- Title:
- INITIATING SYNTHESIS OF MULTIDENTATE LIGANDS WITH SULFUR AND NITROGEN DONORS FOR STUDY OF THEIR COPPER COMPLEXES
- Physical Description:
- Book
- Language:
- English
- Creator:
- Campbell, Melissa
- Publisher:
- New College of Florida
- Place of Publication:
- Sarasota, Fla.
- Publication Date:
- 2014
Thesis/Dissertation Information
- Degree:
- Bachelor's ( B.A.)
- Degree Grantor:
- New College of Florida
- Degree Divisions:
- Natural Sciences
- Area of Concentration:
- Chemistry, Biology
Subjects
- Genre:
- Electronic Thesis or Dissertation
bibliography ( marcgt )
theses ( marcgt )
Notes
- Abstract:
- Blue copper proteins are important metalloproteins that are found in plants and bacteria and are involved in photosynthesis, respiration, oxidative deamination of primary amines and reduction of nitrite reductase. They more specifically are involved in reduction and oxidation reactions, mostly as transporters for electrons. They contain at least one type 1 copper center and are characterized by a sulfur to copper charge transfer giving the proteins a blue color.
Blue copper proteins generally have a reduction potential between +150 and 800 mV (vs NHE) depending on the coordination sphere. The immediate environment of the copper influences the redox potential of the copper which changes the function of the protein. The structure of the coordination sphere is not determined by the metal cofactor but by the protein itself limiting the preferred geometry of the metal ion. Blue copper proteins are very complex, so researchers synthesize models of the copper centers, mimicking the donor atoms and structure around the copper ion as closely as possible. The initial stage of this project consists of synthesizing the model ligand bis(2-(2-thio-1-methylimidazole) ethyl) amine (L) and forming both the copper (I) and
copper (II) complexes, so the structural effects on redox potential can be studied and compared later to other similar complexes. The project was based on and developed from Kenneth Karlin’s work. Three trials of varying ratios of reagents and reaction times were run to determine the best procedure for the model ligand. While the full objective of synthesizing and comparing the copper (I) and copper (II) complexes of the model ligands chosen was not completed, this thesis contains information towards a procedure for the synthesis of the B2T1M ligand.
- Thesis:
- Thesis (B.A.) -- New College of Florida, 2014
- General Note:
- RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
- Bibliography:
- Includes bibliographical references.
- General Note:
- This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
- General Note:
- Faculty Sponsor: Sherman, Suzanne
- Statement of Responsibility:
- by Melissa Campbell
Record Information
- Source Institution:
- New College of Florida
- Holding Location:
- New College of Florida
- Rights Management:
- Applicable rights reserved.
- Resource Identifier:
- Classification:
- S.T. 2014 C3
- System ID:
- AA00024697:00001
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