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A Transcript Analysis of Il-17 Signaling Related Genes in Response to Respiratory Syncytial Virus Infection in Experimen...

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004630/00001

Material Information

Title: A Transcript Analysis of Il-17 Signaling Related Genes in Response to Respiratory Syncytial Virus Infection in Experimental Elastase/Lps Injured Murine Lungs
Physical Description: Book
Language: English
Creator: Mangels, Christopher E.
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2012
Publication Date: 2012

Subjects

Subjects / Keywords: COPD, Murine
Lung
Real time PCR
th17
YST Cells
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Chronic obstructive pulmonary disease (COPD) affects roughly 80 million people worldwide and accounts for 5-10% of global deaths (Chen, Pociask and McAleer 2011). In 2001 close to three million people died due to complications resulting from the disease (Lopez, Mathers and Ezzati 2006). Furthermore, WHO estimates rank COPD as the 4th leading cause of death in the world (Mathers and Loncar 2006). The prevalence and growing threat to global health caused by COPD has translated into abundant research targeted at understanding the underlying mechanisms that govern the disease process. The surge in research has shown an interesting correlation between elevated T helper cell 17 (Th17) cytokine levels, specifically IL-17 and associated signaling, and disease severity. In the current study, Real Time PCR was used to analyze the gene products of IL-17 signaling (IL-23, CCL2, CCL20, CXCL1, CXCL5, and MMP9) in murine mode of COPD.
Statement of Responsibility: by Christopher E. Mangels
Thesis: Thesis (B.A.) -- New College of Florida, 2012
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2012 M277
System ID: NCFE004630:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004630/00001

Material Information

Title: A Transcript Analysis of Il-17 Signaling Related Genes in Response to Respiratory Syncytial Virus Infection in Experimental Elastase/Lps Injured Murine Lungs
Physical Description: Book
Language: English
Creator: Mangels, Christopher E.
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2012
Publication Date: 2012

Subjects

Subjects / Keywords: COPD, Murine
Lung
Real time PCR
th17
YST Cells
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Chronic obstructive pulmonary disease (COPD) affects roughly 80 million people worldwide and accounts for 5-10% of global deaths (Chen, Pociask and McAleer 2011). In 2001 close to three million people died due to complications resulting from the disease (Lopez, Mathers and Ezzati 2006). Furthermore, WHO estimates rank COPD as the 4th leading cause of death in the world (Mathers and Loncar 2006). The prevalence and growing threat to global health caused by COPD has translated into abundant research targeted at understanding the underlying mechanisms that govern the disease process. The surge in research has shown an interesting correlation between elevated T helper cell 17 (Th17) cytokine levels, specifically IL-17 and associated signaling, and disease severity. In the current study, Real Time PCR was used to analyze the gene products of IL-17 signaling (IL-23, CCL2, CCL20, CXCL1, CXCL5, and MMP9) in murine mode of COPD.
Statement of Responsibility: by Christopher E. Mangels
Thesis: Thesis (B.A.) -- New College of Florida, 2012
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2012 M277
System ID: NCFE004630:00001


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PAGE 50

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PAGE 51

! `0 ! ! ! 3 0*45(.>> /..XYH.0$2(",0%$.&%5-($-.(+=JD>E!C@M>!N>K>!@HILJD>E!DF!J!MFH?DJHD!PK>??AK>R!PJKJII@H!>CB>EE>ER!JHE! ?DJ@H>E!N@D=!;t2MD@FHX!?=FN>E! HFKCJL!JLG>FLJK!CFKP=FLFOS< (H!MFHDKJ?DR!LAHO?!IKFC!28*)&!m!CFMV!FK!28*)&m$&4! WE/a!PF?D @HI>MD@FHX!=JE!C@LE!DF!CFE>KJD>!>CP=S?>CJ?!JK>!K>PK>?>HDJD@G>!FI! LAHO?!IKFC!h!E@II>K>HD!C@M>!P>K!OKFAP!GFLAC>!N>@O=D>E!C>JH!JLG>FLJK! GFLAC>!NJ?!MJLMALJD>E!IKFC!C>J?AK>C>HD?!CJE>!F H!JD!L>J?D!Th!KJHEFC!I@>LE?!P>K! ?L@E>JD>E!C@M>!=JE!@HMK>J?>E!GFLAC>!N>@O=D>E!C>JH! JLG>FLJK!GFLAC>!MFCPJK>E!DF!):&!m!CFMV DK>JD>E!C@M>MD@FH!FI!D=>!28*)& DK>JD>E!C@M>!@HMK>J?>E!GFLAC>!N>@O=D>E!C>JH!JLG>FLJK!GFLAC>!N=>H! MFCPJK>E!DF! 28*)&m7FMV DK>JD>E!C@M>!P>K!OKFAPr!EJDJ!K>PFKD>E!J?!C>JH!v!&3r! wE@II>K>HD!IKFC!):&!OKFAPR!)xUK>HD!IKFC!28*)&m7FMV!OKFAPR!)xU! /U b!#K>JDC>HD!FI!28*m$&4! C@M>!JHE!*)&!DK>JDC>HD?! FMMAKK>E!FH!KFDJD@HO!EJS?!>HE@HO!N@D=!$&4!@HI>MD@FH!JD!EJS!U!N>K>! ?ABC@DD>E!DF!H>MKFP?S!JD!EJS?!UR!/R!aR!0R!/UR!JHE!/a!PF?D!@HI>MD@FH
PAGE 52

! `e (HI!"#;,)% "'#!"#)&,-+,+!.3)3+!2'+"%"$,!),==+!"#!%4,!-"&J-/!';!NO*!"#K3&,D!=3#0 ',)3!@?!VHFNH!DF!K>?ALD!@H!D=>!@HMK>J?>E!PKFEAMD@FH!FI!CAMA?!N@D=@H!D=>! LAHO?! W'=>HR!#=J@!JHE!n=JF TUU` X P>K@FE@M!JM@E!&M=@II!W": )"&X!NJ?! A?>E!DF!?DJ@H!CAMA?!PF?@D@G>!M>LL ?!@H!=@?DFLFO@MJL!LAHO!?>MD@FH?!IKFC!BFD=!28*!JHE! ):&!C@M>!JID>K!$&4!@HI>MD@FH!P>K@FE?!W-@OAK>!/ U X!28*!C@M>!HFD!>YPF?>E!DF $&4! W7FMV!@HI>MD@FHX!?JN!J!IFAK IFLE!@HMK>J?>!@H!D=>!JCFAHD!FI!CAMA?!PKFEAM@HO!M>LL?! N=>H!MFCPJK>E!DF! D=>! ):&!CFMV C@M> W-@OAK>! /T X!D=>!$&4!@HI>MD@FH!MJA?>E! JH!@HMK>J?>!@H!CAMA?!PF?@D@G>!M>LL?!@H!BFD=!28*!JHE!):&!C@M>R!D=>!28*m$&4!@H]AKS! K>?ALD>E!@H!J!LJKO>K!HACB>K!FI!": )"&!PF?@D@G>!M>LL?!N@D=@H!D=>!J@KNJS?!JD!JL L!D@C>! PF@HD?!>YJC@H>E!W-@OAK>!/T XE /.XYH.0$2(",0%$.0$"5(8-(-.,<(.$4+9(5.%2.+4"4-.=5%)4"0$*."(''-.0$.,<(.805&8G-. %2 E/LPS injured mice. Lung sections were stained with Alcian Blue and periodic acid Schiff (AB PAS) reagent to identify airway cells containing acidic and neutral mucins. (A) PBS+Mock treated mice did not show and increase in AB PAS positive cells in airways. (B C) RSV infection of the PBS treat ed mice caused transient increase in AB PAS positive cells in large airways. (D) E/LPS+mock treated mice had increased AB PAS positive cells in airways. (E F) RSV infection induced a robust increase in large and small airways of E/LPS treated mice. Images are representative of lungs from 5 different mice per group. (G) The number of AB PAS positive airway cells per 100m basement membrane was quantified from 3 measurements made on all primary and secondary airway from 5 lung lobes. N = 5 mice per group; dat a reported as mean SD; *different from PBS group, P!0.05.

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! 0T Z.+.&03& D+4./.N4 & ?0+4/0'&?4 & EW6./)A.+4*'& ?4 & M)33./.+(. & Cd2 26.08 25.08 5 & Cd247 26.87 27.35 # @jQK & Cd28 32.19 28.94 OjFJ & Cd34 25.17 24.63 @jJQ & Cd3d 27.6 25.29 FjO5 & Cd3e 28.08 25.5 FjJK & Cd3g 29.01 26.57 FjQQ & Cd4 28.54 25.79 FjPJ & Cd40lg 31.18 27.63 OjJJ & Cd8a 28.73 26.61 Fj5F & 80W6O & O@ja5 & O@j@Q & @jKP & Z*4*O & FKjQP & FPjP5 & @jPC & D(0N & FajPP & FCjKP & Fja & D'5J & FPjPQ & FKjOQ & # @jC & D'F & OJ & O@jCP & QjOO & D'FP & O5jFP & O@jCC & @jC5 & D'O & OJ & OJ & @ & D'Q & O5jFP & FajPa & 5jQK & D'J & FajJK & O5jJ5 & # 5jaO & D'P/ & FKj5a & FCjQC & 5jPO & :0/( & FPj55 & FCjOa & @jPF & S,WF5 & OJ & O@jJK & QjQF & ! ! Z.+.&03&D+4./.N4 & ?0+4/0'&?4 & EW6./)A.+4*'& ?4 & M)33./.+(. & `*B5 & FQjFO & FFjPF & 5jJ5 & `*BF & FCjJP & FJjOK & 5j5a & %0(N5 & FKjQK & FPjFC & 5jFF & %0(NO & FPjCP & FPjQP & @jF & %4*4O & FCjJF & FJjFa & 5jFO & %4*4Q & OJ & OQj5Q & @jKC & %4*4J* & FCjJK & FQjCQ & 5jaQ & %4*4C & FJjK & FQj@K & 5jPF & #JBL>!/b!&"!:@F?M@>HM>!(* /0!JKKJS!?@OH JL@HO!EJDJ!PK>?>HD>E!@H!I@OAK>!/h K>HM>!MFLACH!NJ?!E>D>KC@H>E!BS!D=>!IFLLFN@HO!>QAJD@FHb!W'FHDKFL!'DX W2YP>K@C>HDJL!'DXu!3@II>K>HM>R!J?!P>K!CJHAIJMDAK>?!E@K>MD@FH?!T b!&"!:@F?M@>HM>!(* /0!JKKJS!?@OH JL@HO!EJDJ!PK>?>HD>E!@H!I@OAK>! /d K>HM>!MFLACH!NJ?!E>D>KC@H>E!BS!D=>!IFLLFN@HO!>QAJD@FHb! W'FHDKFL!'DX W2YP>K@C>HDJL!'DXu!3@II>K>HM>R!J?!P>K!CJHAIJMDAK>?! E@K>MD@FH?
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! 0` Z.+.&03& D+4./.N4 & ?0+4/0'&?4 & EW6./)A.+4*'& ?4 & M) 33./.+(. & D'FJ & OOjC5 & OOjJa & @j@F & D'5P* & OOjFF & O5jOJ & 5jKP & D'5P( & FKjaO & O@jFO & # 5jO & D'5P1 & FajJJ & FPjKP & 5jCK & D'5P3 & FajKK & FCjJa & OjFa & D'5P/, & FajPJ & FKjO5 & 5jQQ & D'5P/( & FajCP & FKjaQ & @jPO & D'5P/1 & FCjJC & FCjCP & # @j55 & D'5P/. & FCj5Q & FCjOC & # @jFF & D'F5 & OJ & OOjFa & 5jP5 & D'FF & OJ & OJ & @ & ! Z.+.&03& D+4./.N4 & ?0+4/0'&?4 & EW6./)A.+4*'& ?4 & M)33./.+(. & D'5F, & OOjJ & FKjJP & QjaO & D'5F/,5 & OFj5F & O5jQJ & @jCP & D'5F/,F & O5jaF & OFjKF & # @ja & D'5K & FCjK & FCjCF & @j5K & D'5, & FPjQa & FQjKC & FjCO & D'FO* & OJ & OJ & @ & D'FO/ & O5jPQ & FajQP & FjFP & S>3,5 & FQjJK & FQjP & # @j5F & ! #J BL>!` b!&"!:@F?M@>HM>!(* /0!JKKJS!?@OH JL@HO!EJDJ! PK>?>HD>E!@H!I@OAK>! /0 K>HM>!MFLACH!NJ?!E>D>KC@H>E!BS!D=>!IFLLFN@HO!>QAJD@FHb! W'FHDKFL!'DX W2YP>K@C>HDJL!'DXu!3@II>K>HM>R!J?!P>K!CJHAIJMDAK>?! E@K>MD@FH?!a b!&"!:@F?M@>HM>!(* /0!JKKJS!?@OH JL@HO!EJDJ!PK>?>HD>E!@H!I@OAK>! /e K>HM>!MFLACH!N J?!E>D>KC@H>E!BS!D=>!IFLLFN@HO!>QAJD@FHb! W'FHDKFL!'DX W2YP>K@C>HDJL!'DXu!3@II>K>HM>R!J?!P>K!CJHAIJMDAK>?! E@K>MD@FH?
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! 0a Z.+.&03& D+4./.N4 & ?0+4/0'&?4 & EW6./)A.+4*'& ?4 & M)33./.+(. & XA65O & OFj5P & O@jC5 & 5jJC & XA6O & FCjJ5 & FQjO & FjF5 & XA6a & O5jPJ & FPjCP & Qj@K & ! ! ! ! #J BL>!a b!&"!:@F?M@>HM>!(* /0!JKKJS!?@OH JL@HO!EJDJ!PK>?>HD>E!@H!I@OAK>! /f K>HM>!MFLACH!NJ?!E>D>KC@H>E!BS!D=>!IFLLFN@HO!>QAJD@FHb! W' FHDKFL!'DX W2YP>K@C>HDJL!'DXu!3@II>K>HM>R!J?!P>K!CJHAIJMDAK>?! E@K>MD@FH?
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