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The Movement of Inhaled Pristine C60 Through the Small Intestine

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004326/00001

Material Information

Title: The Movement of Inhaled Pristine C60 Through the Small Intestine A Biodistribution Study in Rats
Physical Description: Book
Language: English
Creator: Sokolow, Chase William
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2010
Publication Date: 2010

Subjects

Subjects / Keywords: Buckminsterfullerene
Fullerene
Nanotubes
C60
Justin Timberlake
Pharmacolimetrics
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Buckminsterfullerene C60, the most abundant and stable of the fullerenes, has since its discovery become a key component in thousands of possible applications in the physical and biological sciences. This focus has led to C60 experiencing a steady increase in production. This has lead to an intense wave of research on the potential implications of its increased environmental presence. This thesis project is a part of an overarching study that focuses on the potential biological harm that airborne C60 particles might pose, using rats as a biological model. More specifically, the goal of this thesis project was to investigate the movement of inhaled C60 particles through the small intestine. It was found that the majority of inhaled C60 particles pass through the small intestine between 2 to 6 hours after exposure, displaying almost total clearance after 24 hours. No acute toxicity was observed at the target dosage level of 5 mg/kg. In addition, no C60 absorption by the epithelial cells of the intestine was observed. As mentioned earlier, this study is just a small piece of the puzzle. Further research is necessary to fully evaluate the biological and environmental ramifications of increased fullerene production.
Statement of Responsibility: by Chase William Sokolow
Thesis: Thesis (B.A.) -- New College of Florida, 2010
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Walstrom, Katherine

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2010 S6
System ID: NCFE004326:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004326/00001

Material Information

Title: The Movement of Inhaled Pristine C60 Through the Small Intestine A Biodistribution Study in Rats
Physical Description: Book
Language: English
Creator: Sokolow, Chase William
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2010
Publication Date: 2010

Subjects

Subjects / Keywords: Buckminsterfullerene
Fullerene
Nanotubes
C60
Justin Timberlake
Pharmacolimetrics
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Buckminsterfullerene C60, the most abundant and stable of the fullerenes, has since its discovery become a key component in thousands of possible applications in the physical and biological sciences. This focus has led to C60 experiencing a steady increase in production. This has lead to an intense wave of research on the potential implications of its increased environmental presence. This thesis project is a part of an overarching study that focuses on the potential biological harm that airborne C60 particles might pose, using rats as a biological model. More specifically, the goal of this thesis project was to investigate the movement of inhaled C60 particles through the small intestine. It was found that the majority of inhaled C60 particles pass through the small intestine between 2 to 6 hours after exposure, displaying almost total clearance after 24 hours. No acute toxicity was observed at the target dosage level of 5 mg/kg. In addition, no C60 absorption by the epithelial cells of the intestine was observed. As mentioned earlier, this study is just a small piece of the puzzle. Further research is necessary to fully evaluate the biological and environmental ramifications of increased fullerene production.
Statement of Responsibility: by Chase William Sokolow
Thesis: Thesis (B.A.) -- New College of Florida, 2010
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Walstrom, Katherine

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2010 S6
System ID: NCFE004326:00001


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2 nb&bC-2Eb"& &b2b*/2 3EE6@? 3D26>>3?2 nb&bC-2Eb"& &b2b*/2 EECE@>6CE 3C36??? nb&bC-2Eb"& &b2b*/2 32EC@C63 3CC6?2E2 nb&bC-2Eb"& &b23b*/3 >EEE@?6D C63CC?>2 nb&bC-2Eb"& &b23b*/3 @>3@EC6C? C?6?23C3? nb&bC-2Eb"& &b23b*/3 ?2?ECDE62@2 E36?2??E nb&bC-2Eb"& &b23b*/2 D@DE3>6>DC 3@6>>@CC32 nb&bC-2Eb"& &b23b*/2 DE22E6@@? 3?>6>D>>@@ nb&bC-2Eb"& &b23b*/2 DD?@>D6E@@ 3?26C?E2CDC nb&bC-2Eb"& &b22b*/3 D@E>@D6E 3>D6ED22@D nb&bC-2Eb"& &b22b*/3 D2DD2@6? 3>D6??EDD3 nb&bC-2Eb"& &b22b*/3 D222D263?E 3@36D>EE>?? nb&bC-2Eb"& &b22b*/2 D2E263@ 3@26EE>C> nb&bC-2Eb"& &b22b*/2 D>D2CCC6DE 3@@6?C>>2E nb&bC-2Eb"& &b22b*/2 D3?>3@E6E 3@6EEC22 nb&bC-2Eb"& &b2>b*/3 ECDDE>62@? 3D6@>>3E23 nb&bC-2Eb"& &b2>b*/3 EECD@C>6CDC 3C36?2333 nb&bC-2Eb"& &b2>b*/3 ED>2C>36E32 3E63C3>E nb&bC-2Eb"& &b2>b*/2 3D>3C>E?63> >3>63D23C nb&bC-2Eb"& &b2>b*/2 3CC2D?6@E >>63DD3EDE nb&bC-2Eb"& &b2>b*/2 3D@2D>>D6DE >3?6?3??@ nb&bC-2Eb"& &b2@b*/3 @C3D2DD>62D D>63>2DE nb&bC-2Eb"& &b2@b*/3 @E3?3E@@6@> D>6?232D3 nb&bC-2Eb"& &b2@b*/3 @C3EE?6> D>6>>E>>?@ nb&bC-2Eb"& &b2@b*/2 2C>DD?E@63 @C63@2C>2 nb&bC-2Eb"& &b2@b*/2 2CD?>36D3 @C?62>@?E3 nb&bC-2Eb"& &b2@b*/2 2CCCDCC6E2 @C>6C@E>2 nb&bC-2Eb"& &b2?b*/3 3@@3?D?63> 2@6E>@CC@ nb&bC-2Eb"& &b2?b*/3 3@@?6?@ 2?363D2>E nb&bC-2Eb"& &b2?b*/3 3@2C3DD6C3 2@>6@23DCE> nb&bC-2Eb"& &b2?b*/2 3D?@D@@C6@> >3C63>E23 nb&bC-2Eb"& &b2?b*/2 3E3>2E6?E >26EC@?D> nb&bC-2Eb"& &b2?b*/2 3E232D3C622 >2D6>CECC nb&bC-2Eb"& &b2b*/3 22>3>D3E6@> >D36332E>E nb&bC-2Eb"& &b2b*/3 23C3?@D62D >C6D?3@ nb&bC-2Eb"& &b2b*/3 23C332ED6D> >C6CD?@33 nb&bC-2Eb"& &b2b*/2 3>2E?>C36> 22C6E@E?E nb&bC-2Eb"& &b2b*/2 3?3C32DE6@ 2?E6CD?>CC nb&bC-2Eb"& &b2b*/2 3>?3?2?62 2>36CC223> nb&bC-2Eb"& &b2Cb*/3 3@3@D2D6@D 2@26>EC@3D3

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> nb&bC-2Eb"& &b2Cb*/3 3>???6C? 2>@6E2E nb&bC-2Eb"& &b2Cb*/3 3@E>3263 2@36@>D3E? nb&bC-2Eb"& &b2Cb*/2 DE>C3E6@2C 3?>6ECC3CE> nb&bC-2Eb"& &b2Cb*/2 E?>3>62C3 3??6E@@D33 nb&bC-2Eb"& &b2Cb*/2 ED23?36D@ 3D6?C?D22 nb&bC-2Eb"& &b2Db*/3 3>?>CC6E 2>26@D2C32 nb&bC-2Eb"& &b2Db*/3 3>2E2@3D62D 22C6DE?ED? nb&bC-2Eb"& &b2Db*/3 3>2?>??263 22C62>>>@D nb&bC-2Eb"& &b2Db*/2 333>@3?62D 3E36>>>3E@ nb&bC-2Eb"& &b2Db*/2 33223@6E? 3E26C2>C>D nb&bC-2Eb"& &b2Db*/2 33D23D6CD 3DE632C?32 nb&bC-2Eb"& &b2Eb*/3 2>C@>@C6E @?6>2@D3C2 nb&bC-2Eb"& &b2Eb*/3 2@3@@D26C @326C?>?23 nb&bC-2Eb"& &b2Eb*/3 2>EC>@262@ @E622D>D?@ nb&bC-2Eb"& &b2Eb*/2 32?3?E6> 236EE?2C?@ nb&bC-2Eb"& &b2Eb*/2 322>6? 2E6@3C33 nb&bC-2Eb"& &b2Eb*/2 323?2>6D 2363EDC nb&bC-2Eb"& &b>b*/3 22?>E>D>6D? >D@6D>EC? nb&bC-2Eb"& &b>b*/3 22@@E2263> >D>6?C?DCC nb&bC-2Eb"& &b>b*/3 2@@2?>C26?E @36D@E?>22 nb&bC-2Eb"& &b>b*/2 >@2ED?6>D ?D@6@23D?D nb&bC-2Eb"& &b>b*/2 >2@@E@@E63 ??>6>CD> nb&bC-2Eb"& &b>b*/2 >2DE?26?E ?6?2@?CC nb&bC-2Eb"& &b>3b*/3 nb&bC-2Eb"& &b>3b*/3 nb&bC-2Eb"& &b>3b*/3 nb&bC-2Eb"& &b>3b*/2 nb&bC-2Eb"& &b>3b*/2 nb&bC-2Eb"& &b>3b*/2 nb&bC-2Eb"& &b>2b*/3 nb&bC-2Eb"& &b>2b*/3 nb&bC-2Eb"& &b>2b*/3 nb&bC-2Eb"& &b>2b*/2 nb&bC-2Eb"& &b>2b*/2 nb&bC-2Eb"& &b>2b*/2 nb&bC-2Eb"& &b>>b*/3 nb&bC-2Eb"& &b>>b*/3 nb&bC-2Eb"& &b>>b*/3 nb&bC-2Eb"& &b>>b*/2 nb&bC-2Eb"& &b>>b*/2

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@ nb&bC-2Eb"& &b>>b*/2 0&<+0&#< $# C PQ ## C PQ ## 7C% $< ;$< 3 F F 2 3>>63? 6?D E@63? 3@36@ > F F @ ?2?6> ?3?6 ?26>@ C6@C 36@@ ? @@6CE 226@ >36C 3@36@ F F C F F D ?C63 3226? DD@6?C @@ D6E ?6C E 3 @2D6C> 3?C262 3?6@ 336@ 6C 3 F F 33 F F 32 @C6C @?6C@ @6C2 3@632 >6 3> >@@26E >@>>6@? >@>D63C 6E 63E 3@ 26?@ >6? 3@6D 363 26C 3? F F 3 F F 3C 2?263C >E36@ >236E3 ED62 >6@ 3D F F 3E F F 2 F F 23 F F 22 F F 2> F F 2@ F F 2? @?62 3@6? 2E6E> 236 C263C 2 F F 2C D6C @6>D 62 3@36@ 2D F F 2E >6ED 36EE 26D2 3@36@ > F F >3 F F >2 F F >> F F

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? +0+&; < Sample Count [C60] FY06-066_SmInt_Intestine_O001_Alq1 4293737.926 292.7163586 FY06-066_SmInt_Intestine_O001_Alq1 6603586.687 451.196548 FY06-066_SmInt_Intestine_O001_Alq1 7102694.726 485.4406673 FY06-066_SmInt_Intestine_O001_Alq2 5321787.217 363.2514729 FY06-066_SmInt_Intestine_O001_Alq2 5412307.272 369.4621113 FY06-066_SmInt_Intestine_O001_Alq2 5582188.661 381.1177812 FY06-066_SmInt_Intestine_O002_Alq1 0 0 FY06-066_SmInt_Intestine_O002_Alq1 0 0 FY06-066_SmInt_Intestine_O002_Alq1 0 0 FY06-066_SmInt_Intestine_O002_Alq2 2072450.504 140.3124188 FY06-066_SmInt_Intestine_O002_Alq2 1971052.172 133.3554149 FY06-066_SmInt_Intestine_O002_Alq2 1860692.21 125.7835479 FY06-066_SmInt_Intestine_O003_Alq1 0 0 FY06-066_SmInt_Intestine_O003_Alq1 0 0 FY06-066_SmInt_Intestine_O003_Alq1 0 0 FY06-066_SmInt_Intestine_O003_Alq2 0 0 FY06-066_SmInt_Intestine_O003_Alq2 0 0 FY06-066_SmInt_Intestine_O003_Alq2 0 0 FY06-066_SmInt_Intestine_O004_Alq1 8043670.303 550.0015988 FY06-066_SmInt_Intestine_O004_Alq1 7626025.081 521.3466951 FY06-066_SmInt_Intestine_O004_Alq1 7395449.924 505.5267872 FY06-066_SmInt_Intestine_O004_Alq2 9422851.498 644.6280959 FY06-066_SmInt_Intestine_O004_Alq2 6606192.192 451.3753133 FY06-066_SmInt_Intestine_O004_Alq2 6574185.051 449.1792831 FY06-066_SmInt_Intestine_O005_Alq1 628877.885 41.26798525 FY06-066_SmInt_Intestine_O005_Alq1 591396.21 38.69634374 FY06-066_SmInt_Intestine_O005_Alq1 820365.845 54.40609571 FY06-066_SmInt_Intestine_O005_Alq2 0 0 FY06-066_SmInt_Intestine_O005_Alq2 0 0 FY06-066_SmInt_Intestine_O005_Alq2 0 0 FY06-066_SmInt_Intestine_O006_Alq1 0 0 FY06-066_SmInt_Intestine_O006_Alq1 0 0 FY06-066_SmInt_Intestine_O006_Alq1 0 0 FY06-066_SmInt_Intestine_O006_Alq2 0 0 FY06-066_SmInt_Intestine_O006_Alq2 0 0 FY06-066_SmInt_Intestine_O006_Alq2 0 0 FY06-066_SmInt_Intestine_O007_Alq1 0 0

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FY06-066_SmInt_Intestine_O007_Alq1 0 0 FY06-066_SmInt_Intestine_O007_Alq1 0 0 FY06-066_SmInt_Intestine_O007_Alq2 0 0 FY06-066_SmInt_Intestine_O007_Alq2 0 0 FY06-066_SmInt_Intestine_O007_Alq2 0 0 FY06-066_SmInt_Intestine_O008_Alq1 9028707.48 617.5856247 FY06-066_SmInt_Intestine_O008_Alq1 8738412.12 597.6682758 FY06-066_SmInt_Intestine_O008_Alq1 7111336.101 486.0335575 FY06-066_SmInt_Intestine_O008_Alq2 17088354.14 1170.563097 FY06-066_SmInt_Intestine_O008_Alq2 17757849.98 1216.497631 FY06-066_SmInt_Intestine_O008_Alq2 17795558.27 1219.084821 FY06-066_SmInt_Intestine_O009_Alq1 19667625.29 1347.528528 FY06-066_SmInt_Intestine_O009_Alq1 19465784.29 1333.680088 FY06-066_SmInt_Intestine_O009_Alq1 23419962.25 1604.978748 FY06-066_SmInt_Intestine_O009_Alq2 20971896.19 1437.015382 FY06-066_SmInt_Intestine_O009_Alq2 24074837.75 1649.910172 FY06-066_SmInt_Intestine_O009_Alq2 23779896.51 1629.674066 FY06-066_SmInt_Intestine_O010_Alq1 0 0 FY06-066_SmInt_Intestine_O010_Alq1 0 0 FY06-066_SmInt_Intestine_O010_Alq1 0 0 FY06-066_SmInt_Intestine_O010_Alq2 0 0 FY06-066_SmInt_Intestine_O010_Alq2 0 0 FY06-066_SmInt_Intestine_O010_Alq2 0 0 FY06-066_SmInt_Intestine_O011_Alq1 0 0 FY06-066_SmInt_Intestine_O011_Alq1 0 0 FY06-066_SmInt_Intestine_O011_Alq1 0 0 FY06-066_SmInt_Intestine_O011_Alq2 0 0 FY06-066_SmInt_Intestine_O011_Alq2 0 0 FY06-066_SmInt_Intestine_O011_Alq2 0 0 FY06-066_SmInt_Intestine_O012_Alq1 7317089.443 500.1504249 FY06-066_SmInt_Intestine_O012_Alq1 6410807.921 437.9698745 FY06-066_SmInt_Intestine_O012_Alq1 6935691.234 473.9824517 FY06-066_SmInt_Intestine_O012_Alq2 6848489.327 467.9994736 FY06-066_SmInt_Intestine_O012_Alq2 5990635.864 409.141603 FY06-066_SmInt_Intestine_O012_Alq2 6951469.543 475.0650115 FY06-066_SmInt_Intestine_O013_Alq1 50273902.66 3447.444642 FY06-066_SmInt_Intestine_O013_Alq1 49946914.98 3425.00981 FY06-066_SmInt_Intestine_O013_Alq1 50402175.09 3456.245495 FY06-066_SmInt_Intestine_O013_Alq2 49632216.93 3403.418177 FY06-066_SmInt_Intestine_O013_Alq2 49956565.83 3425.671961

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C FY06-066_SmInt_Intestine_O013_Alq2 50620803.24 3471.245711 FY06-066_SmInt_Intestine_O014_Alq1 8100377.543 553.8923186 FY06-066_SmInt_Intestine_O014_Alq1 11077577.2 758.1598765 FY06-066_SmInt_Intestine_O014_Alq1 8299915.257 567.5827278 FY06-066_SmInt_Intestine_O014_Alq2 8485050.909 580.2850023 FY06-066_SmInt_Intestine_O014_Alq2 9008231.605 616.1807619 FY06-066_SmInt_Intestine_O014_Alq2 8957358.361 612.6903164 FY06-066_SmInt_Intestine_O015_Alq1 0 0 FY06-066_SmInt_Intestine_O015_Alq1 0 0 FY06-066_SmInt_Intestine_O015_Alq1 0 0 FY06-066_SmInt_Intestine_O015_Alq2 0 0 FY06-066_SmInt_Intestine_O015_Alq2 0 0 FY06-066_SmInt_Intestine_O015_Alq2 0 0 FY06-066_SmInt_Intestine_O016_Alq1 0 0 FY06-066_SmInt_Intestine_O016_Alq1 0 0 FY06-066_SmInt_Intestine_O016_Alq1 0 0 FY06-066_SmInt_Intestine_O016_Alq2 0 0 FY06-066_SmInt_Intestine_O016_Alq2 0 0 FY06-066_SmInt_Intestine_O016_Alq2 0 0 FY06-066_SmInt_Intestine_O017_Alq1 3350358.929 227.9905269 FY06-066_SmInt_Intestine_O017_Alq1 4773987.193 325.6665656 FY06-066_SmInt_Intestine_O017_Alq1 2984123.835 202.8629046 FY06-066_SmInt_Intestine_O017_Alq2 5040034.527 343.920242 FY06-066_SmInt_Intestine_O017_Alq2 6644243.4 453.9860309 FY06-066_SmInt_Intestine_O017_Alq2 5522485.863 377.0215343 FY06-066_SmInt_Intestine_O018_Alq1 0 0 FY06-066_SmInt_Intestine_O018_Alq1 0 0 FY06-066_SmInt_Intestine_O018_Alq1 0 0 FY06-066_SmInt_Intestine_O018_Alq2 0 0 FY06-066_SmInt_Intestine_O018_Alq2 0 0 FY06-066_SmInt_Intestine_O018_Alq2 0 0 FY06-066_SmInt_Intestine_O019_Alq1 0 0 FY06-066_SmInt_Intestine_O019_Alq1 0 0 FY06-066_SmInt_Intestine_O019_Alq1 0 0 FY06-066_SmInt_Intestine_O019_Alq2 0 0 FY06-066_SmInt_Intestine_O019_Alq2 0 0 FY06-066_SmInt_Intestine_O019_Alq2 0 0 FY06-066_SmInt_Intestine_O020_Alq1 0 0 FY06-066_SmInt_Intestine_O020_Alq1 0 0 FY06-066_SmInt_Intestine_O020_Alq1 0 0

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D FY06-066_SmInt_Intestine_O020_Alq2 0 0 FY06-066_SmInt_Intestine_O020_Alq2 0 0 FY06-066_SmInt_Intestine_O020_Alq2 0 0 FY06-066_SmInt_Intestine_O021_Alq1 0 0 FY06-066_SmInt_Intestine_O021_Alq1 0 0 FY06-066_SmInt_Intestine_O021_Alq1 0 0 FY06-066_SmInt_Intestine_O021_Alq2 0 0 FY06-066_SmInt_Intestine_O021_Alq2 0 0 FY06-066_SmInt_Intestine_O021_Alq2 0 0 FY06-066_SmInt_Intestine_O022_Alq1 0 0 FY06-066_SmInt_Intestine_O022_Alq1 0 0 FY06-066_SmInt_Intestine_O022_Alq1 0 0 FY06-066_SmInt_Intestine_O022_Alq2 0 0 FY06-066_SmInt_Intestine_O022_Alq2 0 0 FY06-066_SmInt_Intestine_O022_Alq2 0 0 FY06-066_SmInt_Intestine_O023_Alq1 0 0 FY06-066_SmInt_Intestine_O023_Alq1 0 0 FY06-066_SmInt_Intestine_O023_Alq1 0 0 FY06-066_SmInt_Intestine_O023_Alq2 0 0 FY06-066_SmInt_Intestine_O023_Alq2 0 0 FY06-066_SmInt_Intestine_O023_Alq2 0 0 FY06-066_SmInt_Intestine_O024_Alq1 0 0 FY06-066_SmInt_Intestine_O024_Alq1 0 0 FY06-066_SmInt_Intestine_O024_Alq1 0 0 FY06-066_SmInt_Intestine_O024_Alq2 0 0 FY06-066_SmInt_Intestine_O024_Alq2 0 0 FY06-066_SmInt_Intestine_O024_Alq2 0 0 FY06-066_SmInt_Intestine_O025_Alq1 720214.332 47.53463684 FY06-066_SmInt_Intestine_O025_Alq1 697436.494 45.97183492 FY06-066_SmInt_Intestine_O025_Alq1 640748.171 42.0824131 FY06-066_SmInt_Intestine_O025_Alq2 362872.403 23.01718031 FY06-066_SmInt_Intestine_O025_Alq2 360100.603 22.82700535 FY06-066_SmInt_Intestine_O025_Alq2 0 0 FY06-066_SmInt_Intestine_O026_Alq1 0 0 FY06-066_SmInt_Intestine_O026_Alq1 0 0 FY06-066_SmInt_Intestine_O026_Alq1 0 0 FY06-066_SmInt_Intestine_O026_Alq2 0 0 FY06-066_SmInt_Intestine_O026_Alq2 0 0 FY06-066_SmInt_Intestine_O026_Alq2 0 0 FY06-066_SmInt_Intestine_O027_Alq1 0 0

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