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BCL-2 Mediated Apoptosis

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004177/00001

Material Information

Title: BCL-2 Mediated Apoptosis The Role of Noxa in the Removal of Mucous Cells from the Metaplastic Human Airway Epithelium
Physical Description: Book
Language: English
Creator: Sokolow, Andrew Cory
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2009
Publication Date: 2009

Subjects

Subjects / Keywords: Apoptosis
Noxa
Asthma
COPD
Lung
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The cytokine interferon-gamma (IFN-gamma) induces Bcl-2 mediated cell death in epithelial cells. Disruption of this process leads to mucus hypersecretions in the human airway epithelium. Apoptosis by IFN-gamma is essential for the removal of the inflammation-induced mucous cells causing the excess mucous. This buildup of mucus is the underlying cause for airflow obstruction and death caused by asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). This study demonstrates that the BH-3 only protein Noxa sensitizes human airway epithelial cells (HAECs) to IFN-gamma induced apoptosis. Noxa promotes apoptosis by interfering with transcription factor NF-kappaB. A single line of HAECs (AALEBs) transfected with Noxa siRNA exhibited reduced sensitivity to IFN-gamma associated with decreased levels of cytosolic NF-kappaB. Findings from this study suggest a novel method of NFkappaB activity inhibition by Noxa.
Statement of Responsibility: by Andrew Cory Sokolow
Thesis: Thesis (B.A.) -- New College of Florida, 2009
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Demski, Leo

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2009 S68
System ID: NCFE004177:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE004177/00001

Material Information

Title: BCL-2 Mediated Apoptosis The Role of Noxa in the Removal of Mucous Cells from the Metaplastic Human Airway Epithelium
Physical Description: Book
Language: English
Creator: Sokolow, Andrew Cory
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2009
Publication Date: 2009

Subjects

Subjects / Keywords: Apoptosis
Noxa
Asthma
COPD
Lung
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The cytokine interferon-gamma (IFN-gamma) induces Bcl-2 mediated cell death in epithelial cells. Disruption of this process leads to mucus hypersecretions in the human airway epithelium. Apoptosis by IFN-gamma is essential for the removal of the inflammation-induced mucous cells causing the excess mucous. This buildup of mucus is the underlying cause for airflow obstruction and death caused by asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). This study demonstrates that the BH-3 only protein Noxa sensitizes human airway epithelial cells (HAECs) to IFN-gamma induced apoptosis. Noxa promotes apoptosis by interfering with transcription factor NF-kappaB. A single line of HAECs (AALEBs) transfected with Noxa siRNA exhibited reduced sensitivity to IFN-gamma associated with decreased levels of cytosolic NF-kappaB. Findings from this study suggest a novel method of NFkappaB activity inhibition by Noxa.
Statement of Responsibility: by Andrew Cory Sokolow
Thesis: Thesis (B.A.) -- New College of Florida, 2009
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Demski, Leo

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2009 S68
System ID: NCFE004177:00001


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