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Cognition and Memory in the Goldfish (Carassius Auratus)

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003665/00001

Material Information

Title: Cognition and Memory in the Goldfish (Carassius Auratus) A Study Exploring the Novel Serotonin Antagonist, SB-258585
Physical Description: Book
Language: English
Creator: Mackin, Nick
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2006
Publication Date: 2006

Subjects

Subjects / Keywords: Goldfish
Serotonin
Learning
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The common goldfish, Carassius Auratus, was tested in a two way avoidance learning shuttle box paradigm. Research in mammals and now in teleosts strongly suggests a negative correlation between avoidance in this task and increased serotonergic activity. Forty five subjects were divided into three groups according to drug treatment. Fluoxetine, as an SSRI, was used to increase the concentration of serotonin in the synapses of the central nervous system, and a highly selective antagonist for the 5-HT6 site, SB-258585, was used in comparison. The drugs were delivered right into the aquaria via pipet once both drugs were diluted. The subjects were trained for 23 sessions, 15 trials per session. As hypothesized, SB-258585 treated subjects consistently and significantly avoided and escaped more than the other two groups. And, on the contrary, the Fluoxetine treated group clearly and significantly avoided less, and consequently failed more. Increased escape activity in the 5-HT6 blocked group is presumed to have allowed the subjects to learn the paradigm quicker, while the large number of failures suggests that satiety factored into the motivational states of the subjects. This study has demonstrated significant drug effects on subjects� overall performance. Serotonin is implicated in limbic related memory consolidation, cognition, and motor functioning. This study warrants future investigations concerning serotonin and this paradigm, but it is clear that SB-258585 is a very potent antagonist.
Statement of Responsibility: by Nick Mackin
Thesis: Thesis (B.A.) -- New College of Florida, 2006
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2006 M15
System ID: NCFE003665:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003665/00001

Material Information

Title: Cognition and Memory in the Goldfish (Carassius Auratus) A Study Exploring the Novel Serotonin Antagonist, SB-258585
Physical Description: Book
Language: English
Creator: Mackin, Nick
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2006
Publication Date: 2006

Subjects

Subjects / Keywords: Goldfish
Serotonin
Learning
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The common goldfish, Carassius Auratus, was tested in a two way avoidance learning shuttle box paradigm. Research in mammals and now in teleosts strongly suggests a negative correlation between avoidance in this task and increased serotonergic activity. Forty five subjects were divided into three groups according to drug treatment. Fluoxetine, as an SSRI, was used to increase the concentration of serotonin in the synapses of the central nervous system, and a highly selective antagonist for the 5-HT6 site, SB-258585, was used in comparison. The drugs were delivered right into the aquaria via pipet once both drugs were diluted. The subjects were trained for 23 sessions, 15 trials per session. As hypothesized, SB-258585 treated subjects consistently and significantly avoided and escaped more than the other two groups. And, on the contrary, the Fluoxetine treated group clearly and significantly avoided less, and consequently failed more. Increased escape activity in the 5-HT6 blocked group is presumed to have allowed the subjects to learn the paradigm quicker, while the large number of failures suggests that satiety factored into the motivational states of the subjects. This study has demonstrated significant drug effects on subjects� overall performance. Serotonin is implicated in limbic related memory consolidation, cognition, and motor functioning. This study warrants future investigations concerning serotonin and this paradigm, but it is clear that SB-258585 is a very potent antagonist.
Statement of Responsibility: by Nick Mackin
Thesis: Thesis (B.A.) -- New College of Florida, 2006
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2006 M15
System ID: NCFE003665:00001

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