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The Localization of RNA Helicase A in the Caenorhabditis Elegans Hermaphrodite Using Immunocytochemisty

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003370/00001

Material Information

Title: The Localization of RNA Helicase A in the Caenorhabditis Elegans Hermaphrodite Using Immunocytochemisty
Physical Description: Book
Language: English
Creator: Gallo, Katherine Cory
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: C. elegans
RHA Helicase Germline Development
Soma-Germline Interactions
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Molecular and genetic defects in germline development are the cause of many infertility cases but remain poorly understood. Elucidation of emerging germline processes such as posttranscriptional regulation and soma-germline communication will lead to a better understanding of the pathogenesis of germline disease and may lead to the development of more effective infertility therapies. The analysis of germline development can be facilitated by the characterization of proteins that regulate germline processes. RNA Helicase A (RHA) is a highly conserved protein with homologs in the human, mouse, bovine, Drosophila, and Caenorhabditis elegans (C. elegans) where it has been associated with germline development. Previous studies suggest that in C. elegans, the involvement of RHA-1 in the regulation of germline development may be related to its ability to process RNA. Based on this, it has been postulated that in C. elegans RHA-1 could be involved in the posttranscriptional regulation. In order to gain further insight into the nature of RHA-1 and its role in the regulation of germline development, the location of RHA-1 within the C. elegans hermaphrodite was determined using immunocytochemical techniques. The results of this investigation demonstrate that RHA-1 is located in the sheath cells of the C. elegans somatic gonad. This finding leads to the speculation that RHA-1 may be involved in the posttranscriptional regulation of germline RNAs from a location within the somatic gonad.
Statement of Responsibility: by Katherine Cory Gallo
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Walstrom, Katherine

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 G1
System ID: NCFE003370:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003370/00001

Material Information

Title: The Localization of RNA Helicase A in the Caenorhabditis Elegans Hermaphrodite Using Immunocytochemisty
Physical Description: Book
Language: English
Creator: Gallo, Katherine Cory
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: C. elegans
RHA Helicase Germline Development
Soma-Germline Interactions
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Molecular and genetic defects in germline development are the cause of many infertility cases but remain poorly understood. Elucidation of emerging germline processes such as posttranscriptional regulation and soma-germline communication will lead to a better understanding of the pathogenesis of germline disease and may lead to the development of more effective infertility therapies. The analysis of germline development can be facilitated by the characterization of proteins that regulate germline processes. RNA Helicase A (RHA) is a highly conserved protein with homologs in the human, mouse, bovine, Drosophila, and Caenorhabditis elegans (C. elegans) where it has been associated with germline development. Previous studies suggest that in C. elegans, the involvement of RHA-1 in the regulation of germline development may be related to its ability to process RNA. Based on this, it has been postulated that in C. elegans RHA-1 could be involved in the posttranscriptional regulation. In order to gain further insight into the nature of RHA-1 and its role in the regulation of germline development, the location of RHA-1 within the C. elegans hermaphrodite was determined using immunocytochemical techniques. The results of this investigation demonstrate that RHA-1 is located in the sheath cells of the C. elegans somatic gonad. This finding leads to the speculation that RHA-1 may be involved in the posttranscriptional regulation of germline RNAs from a location within the somatic gonad.
Statement of Responsibility: by Katherine Cory Gallo
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Walstrom, Katherine

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 G1
System ID: NCFE003370:00001

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