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Fish on Prozac

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003368/00001

Material Information

Title: Fish on Prozac The Effects of Serotonergic Manipulation on Avoidance Learning in the Goldfish (Carassius Auratus)
Physical Description: Book
Language: English
Creator: Fowler, Jonathan
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: Teleost
Serotonin
Shuttle Box
Goldfish
Avoidance Learning
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Researchers have suggested a conservation of serotonergic function across vertebrate sub-phyla. Relatively little work, however, has been done to confirm this suggestion, especially in teleosts. Behavioral responses to serotonin manipulation offer an appropriate assessment of this issue. Goldfish, Carassius auratus, were tested in a two-way active avoidance leaming (shuttle box) procedure. Research in mammals suggests a negative correlation between serotonergic activity and avoidance performance in this task. Similar results were expected in Carassius. Subjects were divided into three groups according to phar-macological treatment. The SSRI fluoxetine (Prozac) was used to potentiate serotonergic transmission, while the selective 5-HTI A antagonist WAY 100,635 (WAY) was used to inhibit serotonergic transmission. Drugs were delivered via direct introduction to aquaria to facilitate chronic exposure. A control group received 'sham' treatments of water. Subjects were trained for 13 sessions, 15 trials per session. As expected., WAY-treated subjects performed consistently better than control- or fluoxetine-treated groups, as measured by the number of avoidance responses. A two- way ANOVA revealed significant differences between mean avoidance performance (p = .0079). Fluoxetine-treated subjects performed on a level comparable to controls. It is suggested that exhaustive training or variation of dose may have resulted in fluoxetineinduced impairment of performance. The results offer support for the suggestion that serotonergic function has been phylogenetically preserved across vertebrates. The results are intriguing at the very least, and certainly warrant future investigations.
Statement of Responsibility: by Jonathan Fowler
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 F7
System ID: NCFE003368:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003368/00001

Material Information

Title: Fish on Prozac The Effects of Serotonergic Manipulation on Avoidance Learning in the Goldfish (Carassius Auratus)
Physical Description: Book
Language: English
Creator: Fowler, Jonathan
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: Teleost
Serotonin
Shuttle Box
Goldfish
Avoidance Learning
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Researchers have suggested a conservation of serotonergic function across vertebrate sub-phyla. Relatively little work, however, has been done to confirm this suggestion, especially in teleosts. Behavioral responses to serotonin manipulation offer an appropriate assessment of this issue. Goldfish, Carassius auratus, were tested in a two-way active avoidance leaming (shuttle box) procedure. Research in mammals suggests a negative correlation between serotonergic activity and avoidance performance in this task. Similar results were expected in Carassius. Subjects were divided into three groups according to phar-macological treatment. The SSRI fluoxetine (Prozac) was used to potentiate serotonergic transmission, while the selective 5-HTI A antagonist WAY 100,635 (WAY) was used to inhibit serotonergic transmission. Drugs were delivered via direct introduction to aquaria to facilitate chronic exposure. A control group received 'sham' treatments of water. Subjects were trained for 13 sessions, 15 trials per session. As expected., WAY-treated subjects performed consistently better than control- or fluoxetine-treated groups, as measured by the number of avoidance responses. A two- way ANOVA revealed significant differences between mean avoidance performance (p = .0079). Fluoxetine-treated subjects performed on a level comparable to controls. It is suggested that exhaustive training or variation of dose may have resulted in fluoxetineinduced impairment of performance. The results offer support for the suggestion that serotonergic function has been phylogenetically preserved across vertebrates. The results are intriguing at the very least, and certainly warrant future investigations.
Statement of Responsibility: by Jonathan Fowler
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 F7
System ID: NCFE003368:00001

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