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Off the Beaten Pathogen

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003333/00001

Material Information

Title: Off the Beaten Pathogen Glucocorticoids and the Evolution of the Immune System
Physical Description: Book
Language: English
Creator: Azpiazu, Alfredo
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: Stress
Evolution
Glucocorticoids
Immunology
Cortisol
Immune System
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The purpose of this work was to create working models of the evolution of the immune system and the effect of glueocorticoids on the human immune system. To complete this, a review of the human immune system was first undertaken to serve as a model for what the evolution section would be building towards, while providing a substrate for the discussion on the effect of glucocorticoids on that system. Innate immunity, which is limited by its allotted space in the genome, was theorized to be the result of ancient polymorphism-detection mechanisms turned inward. The adaptive immune system, which can generate countless antigen receptors through random genetic rearrangement, was thought to have emerged as the result of a chromosomal gene duplication and the horizontal transfer of what would become the RAG genes in a common ancestor of the gnathostomes. A phylogenetic study of different species immune capability accompanied these revelations. The effect of glucocorticoids, a group of stress hormones, on the human immune system was then examined. Though once thought to have a solely negative impact on this system, it was shown that limited amounts of stress augment immune function, while chronic stress can drastically reduce it, as well as contribute to some forms of dementia.
Statement of Responsibility: by Alfredo Azpiazu
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 A9
System ID: NCFE003333:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003333/00001

Material Information

Title: Off the Beaten Pathogen Glucocorticoids and the Evolution of the Immune System
Physical Description: Book
Language: English
Creator: Azpiazu, Alfredo
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2004
Publication Date: 2004

Subjects

Subjects / Keywords: Stress
Evolution
Glucocorticoids
Immunology
Cortisol
Immune System
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The purpose of this work was to create working models of the evolution of the immune system and the effect of glueocorticoids on the human immune system. To complete this, a review of the human immune system was first undertaken to serve as a model for what the evolution section would be building towards, while providing a substrate for the discussion on the effect of glucocorticoids on that system. Innate immunity, which is limited by its allotted space in the genome, was theorized to be the result of ancient polymorphism-detection mechanisms turned inward. The adaptive immune system, which can generate countless antigen receptors through random genetic rearrangement, was thought to have emerged as the result of a chromosomal gene duplication and the horizontal transfer of what would become the RAG genes in a common ancestor of the gnathostomes. A phylogenetic study of different species immune capability accompanied these revelations. The effect of glucocorticoids, a group of stress hormones, on the human immune system was then examined. Though once thought to have a solely negative impact on this system, it was shown that limited amounts of stress augment immune function, while chronic stress can drastically reduce it, as well as contribute to some forms of dementia.
Statement of Responsibility: by Alfredo Azpiazu
Thesis: Thesis (B.A.) -- New College of Florida, 2004
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2004 A9
System ID: NCFE003333:00001

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