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A Fatal Attraction

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003253/00001

Material Information

Title: A Fatal Attraction HIV-1 and DC-Sign
Physical Description: Book
Language: English
Creator: Latshaw, Sara
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2003
Publication Date: 2003

Subjects

Subjects / Keywords: HIV-1
DC-Sign
Virology
AIDS
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: In 2002, AIDS was estimated to have taken over 3 million lives with little hope for a cure in sight (UNAIDS, 2002). As the treatments available for HIV continue to advance, so does the understanding of the virus itself. Recently the discovery of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC- SIGN) has provided a new target for HIV research. This dendritic cell surface receptor functions in the immune system as receptor for transendothelial migration and DC-T cell interaction. It has also been found to bind to the HIV receptor gp l2O with high affinity. This thesis outlines DC-SIGN's function in the body and how this relates to its interactions with HIV-1. The role of DC-SIGN mediated cis- and trans-infection of cells as well as its role in vertical and horizontal transmission of HIV- 1 is investigated. Additionally, the necessary future research on this topic is outlined.
Statement of Responsibility: by Sara Latshaw
Thesis: Thesis (B.A.) -- New College of Florida, 2003
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2003 L36
System ID: NCFE003253:00001

Permanent Link: http://ncf.sobek.ufl.edu/NCFE003253/00001

Material Information

Title: A Fatal Attraction HIV-1 and DC-Sign
Physical Description: Book
Language: English
Creator: Latshaw, Sara
Publisher: New College of Florida
Place of Publication: Sarasota, Fla.
Creation Date: 2003
Publication Date: 2003

Subjects

Subjects / Keywords: HIV-1
DC-Sign
Virology
AIDS
Genre: bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: In 2002, AIDS was estimated to have taken over 3 million lives with little hope for a cure in sight (UNAIDS, 2002). As the treatments available for HIV continue to advance, so does the understanding of the virus itself. Recently the discovery of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC- SIGN) has provided a new target for HIV research. This dendritic cell surface receptor functions in the immune system as receptor for transendothelial migration and DC-T cell interaction. It has also been found to bind to the HIV receptor gp l2O with high affinity. This thesis outlines DC-SIGN's function in the body and how this relates to its interactions with HIV-1. The role of DC-SIGN mediated cis- and trans-infection of cells as well as its role in vertical and horizontal transmission of HIV- 1 is investigated. Additionally, the necessary future research on this topic is outlined.
Statement of Responsibility: by Sara Latshaw
Thesis: Thesis (B.A.) -- New College of Florida, 2003
Electronic Access: RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography: Includes bibliographical references.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Local: Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution: New College of Florida
Holding Location: New College of Florida
Rights Management: Applicable rights reserved.
Classification: local - S.T. 2003 L36
System ID: NCFE003253:00001

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