New College of Florida Brilliantly Unique; Uniquely Brilliant

The Effects of Chronic Pain on Neurophysiology and Long Term Potentiation

Material Information

Title:
The Effects of Chronic Pain on Neurophysiology and Long Term Potentiation
Physical Description:
Book
Language:
English
Creator:
Martini, Catherine
Publisher:
New College of Florida
Place of Publication:
Sarasota, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Bachelor's ( B.A.)
Degree Grantor:
New College of Florida
Degree Divisions:
Natural Sciences
Area of Concentration:
Neurobiology
Faculty Sponsor:
Beulig, Alfred

Subjects

Genre:
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, territorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
This thesis examines the effects of chronic pain on neurophysiology and long term potentiation (LTP). In the first part, the thesis reviews the path of nociceptive signaling as well as the major pain processing centers within the brain. The second part delves into an overview of synaptic plasticity (i.e. LTP) and central sensitization including the roles of receptors, glial cells, inflammatory cytokines, and the ERK/MAPK pathway. The third part attends to the effects of chronic pain on memory and attention as well as the possible effects of current drug treatments on both. The final part examines the physical effect of chronic pain on morphology of the brain as well as the comorbidity with chronic stress. In conclusion, this thesis asserts that chronic pain has a negative effect upon neurophysiology of memory and attention. Moreover, research on pain requires more focus on the mechanisms involved in the stimulation and perpetuation of the chronic pain state such that a means of prevention or reversal can be formulated.
Statement of Responsibility:
by Catherine Martini
Thesis:
Thesis (B.A.) -- New College of Florida, 2014
General Note:
RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE
Bibliography:
Includes bibliographical references.
General Note:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
General Note:
Faculty Sponsor: Beulig, Alfred

Record Information

Source Institution:
New College of Florida
Holding Location:
New College of Florida
Rights Management:
Applicable rights reserved.
Resource Identifier:
Classification:
S.T. 2014 M37
System ID:
AA00024769:00001

Facebook Twitter YouTube Regulations - Careers - Contact UsA-Z Index - Google+

New College of Florida  •  5800 Bay Shore Road  •  Sarasota, FL 34243  •  (941) 487-5000